Abstract: In this paper, flotation desulfurization experiments were carried out for a high-sulfur fine-grained embedded bauxite in Gansu Province. The experimental results show that bauxite concentrate with sulfur content of 0.38% can be obtained by closed-circuit flotation with grinding to-200 mesh 90%, pH value of 8.4, dosage of collector butyl xanthate and Z-200 200 200 200 at 200 g/t and 50 g/t, respectively. The desulfurization rate is 95.01%, and bauxite concentrate with sulfur content of 0.38%. Beneficiation index of 91.06% recovery of earth and ore. The bauxite concentrate with sulfur content of 0.38% obtained by flotation desulfurization process meets the requirement that sulfur content in Bayer process of alumina is not higher than 0.4%. At the same time, sulfur concentrate can be used as raw material for sulfuric acid production. The tailings of the whole flotation desulfurization process are zero-emission, thus realizing the efficient and comprehensive utilization of mineral resources.