Abstract: In this paper, the typical vanadium-titanium magnetite tailings in Panzhihua area were taken as the research object, the metal leaching experiments were carried out under the conditions of pH value, ambient temperature, liquid-solid ratio, time and particle size. The results showed that the leaching concentration of Co, Cr, Cu, Fe, Mn, Ni, Ti and Zn were significantly affected by pH, ambient temperature and liquid-solid ratio of the extract, and low pH, high temperature and high liquid-solid ratio were favorable for the leaching of metal elements. The leaching concentration of most metals (Co, Cr, Fe, Mn, Ni and Ti) is inversely proportional to the particle size. Most metals in iron tailings (Co, Cr, Fe, Mn, Ni and Zn) have a long release duration. For the prevention and control of heavy metal pollution in iron tailings, the change of metal pollution caused by seasonal changes should be considered, and emphasis should be focus on the prevention and control of summers with high rainfall, long duration of rainfall and high temperature, and the greater metal release of fine particle size iron tailings.