Abstract: a Copper Mine of Gansu is a single copper ore and a disseminated pyrite.The research results showed that some liberated chalcopyrite and rich aggregate into tailings,and this is the main causes of copper loss.Through the experiment research,The good technical index of small scale tests and pulp sample tests was obtained by a new reagent D60 as the collector,Without changing the situation of the production process,By this method,Copper concentrate recovery rate was improved above 1%, compared with the on-site production.