Abstract: The grade of Cu taken from Sichuan mixed copper ore is 0.77%, Ag8.2g/t, copper minerals mainly contain copper sulfide, such as chalcocite and so on, copper oxide minerals is mainly malachites, the oxidation rate of the copper is 16.88%, the combined copper oxide accounts for 10.39%, and the mixed copper ore is a low grade. According to the characteristics of the ore, the article conducts the copper sulfide flotation firstly, and then conducts the copper oxide flotation. Under the conditions of appropriate grinding and reagent system, the technical flowsheet of the closed-circuit tests is a period of grinding, twice roughing, once cleaning, and once scavenging. A copper concentrate containing Cu 25.76% with recovery rate of 85.74% including Ag 258.21g/t can be finally obtained.