Abstract: The floatation experiment of a high content of pyrrhotite, low grade and close associated relationship Pb-Zn ore from Sichuan was investigated. Adopting a flowsheet consisting of a Pb selective flotation, a magnetic separation of desulphurization, and a Zn-S separation of mixed flotation concentrate, Pb concentrate with Pb grade and recovery of 62.37% and 86.75%, Zn concentrate with Zn grade and recovery of 46.46% and 83.13%, S concentrate with S grade and recovery of 39.10% and 82.37%, respectively, were produced,and also provided some reference to the scientific and rational recovery of polymetallic ore.