Abstract: Based on the properties of the refractory oxidation-sulfidation lead-zinc bulk ore in Ningnan, the preferred and full flotation process of flotation of oxide minerals after that of sulfide minerals was determined. The small closed-circuit test was carried on the basis of the condition test. Finally, the lead sulfide concentrate with the Pb grade of 73.01% and recovery of 64.73%, the zinc sulfide concentrate with the zinc grade of 43.54% and recovery of 29.88%, the lead oxide concentrate with the lead grade of 51.44% and recovery of 30.77% and the zinc oxide concentrate with the zinc grade of 26.88% and recovery of 37.32% were obtained. The flotation process of preliminary desliming and middling further desliming was adopted for zinc oxide ores, which can improve the flotation performance of zinc oxide ores and make the flotation flowsheet more unobstructed.