Abstract: This is an article in the field of mineral processing engineering. The comprehensive recovery test of silver, gold and copper bearing sulfide concentrate was carried out. With isobutyl xanthate and sodium diethyl dithiocarbamate as a combined collector, calcium oxide as the depressant, 2^# oil as a frother, which produced a concentrate approaching 16.66% Cu grade at 86.96% recovery, Au content of 278.95 g/t at 75.56% Au recovery and Ag content of 1848.74 g/t at 78.55% Ag recovery by a flotation process consisting of one stage of roughing, three stages of cleaning and two stages of scavenging was used to collect lead minerals. The comprehensive recovery of copper from sulfur concentrate has been effectively realized. At the same time, gold and silver are well enriched in copper concentrate, which is convenient for recovery and utilization, and the mineral processing index is ideal.