Abstract: This is an article in the field of earth sciences. Xidamingshan polymetallic ore concentration area is critical mineral prospecting district in Guangxi. With the promotion of the large-scale mineral breakthrough work, the Xidamingshan mineral exploration, the Nongtun large-scale Pb-Zn deposit has been newly discovered. However, the understanding of the metallogenic characteristics of the deposit, especially the genesis of the deposit, is still at the superficial stage. Based on detailed field geological investigations and previous work, this paper systematically summarizes the regional metallogenic geological background, mining area and geological characteristics, and analyzes the genesis of the Nongtun lead-zinc deposit to find out the metallogenic mechanism. The study shows the Nongtun Pb-Zn deposit is related-magmatic hydrothermal deposit, the ore-forming fluids originated from magmatic, and later mixed with meteoric water. The fluids extracted Pb and Zn ore-forming elements from the strata during long-distance transport, and combined with S of magmatic fluids to synthesize HS^-ligand that converged in the fracture zone and transported to the shallow part, thus forming Pb-Zn ore vein. The above research results have established the metallogenic model of the Nongtun Pb-Zn deposit, which provides a good guidance for prospecting prediction and exploration.