Abstract: This is an essay in the field of mineral processing engineering. A molybdenum mine in Henan Province belongs to the skarn type molybdenum mine, which has the characteristics of extremely fine embedded particle size and high mud mineral content, and the molybdenum has suffered poor recovery. This paper systematically analyzed the ore properties and production status and analyzed the main problems existing in the production. In order to meet the needs of the 4000 t/d capacity expansion and reconstruction of the ore dressing plant, and to synergistically strengthen the recovery of fine-grained molybdenite particles, a cyclonic-static microbubble flotation column was proposed to add combined with the structural characteristics and separation advantages. The research results show that the molybdenum ore was embedded with micro-fine size, and -0.038 mm and -0.020 mm molybdenite accounted for 75.80% and 38.68%, respectively. Moreover, the ores contained a large amount of epidote, montmorillonite, chlorite and other argillaceous minerals, and the content of argillaceous minerals in some pit mouths was more than 40%. The existing flotation process has suffered poor recovery in the fine-grained particles, and the loss of molybdenum with -0.020 mm size in the tailings accounted for more than 50%. Laboratory flotation test results show that the cyclone-static microbubble flotation column had a good flotation effect on molybdenum recovery in total tailings and rougher tailings, and the concentrate enrichment ratio and molybdenum recovery rate were obviously better than flotation machine. The engineering practice further shows that the cyclone-static microbubble flotation column played a role in regaining better recovery for the existing flotation column, and the molybdenum recovery rate after the expansion was increased by more than 4 percentage points, and the loss of fine-grained molybdenite particles in tailings were significantly reduced, which achieved significant economic benefits.