Abstract: This is a paper in the field of metallurgical engineering. It aims to find out the coupling law of average particle size and hydrolysis rate of hydrolyzed products determined by titanium hydrolyzed process parameters, so as to improve the properties and quality of hydrolyzed products. Response surface methodology was used to establish a mathematical model of the relationship between hydrolysis temperature, initial concentration of titanium liquid, F value of titanium liquid, hydrolysis time, average particle size and hydrolysis rate. The correctness of the mathematical model was verified by variance analysis and test indexes. Hydrolysis temperature had a significant effect on the average particle size, and the average particle size was inversely proportional to hydrolysis temperature. The hydrolysis temperature has the most significant effect on the hydrolysis rate, followed by the initial concentration of titanium solution. The increase of the concentration of titanium solution makes the hydrolysis increase first and then decrease. With the increase of hydrolysis temperature, the first step of hydrolysis decreases. Taking the average particle size of 2 µm and the highest hydrolysis rate as the objective parameters, the errors between the predicted value and the actual value of hydrolysis rate were 2.86% and 2.01%, respectively, which further verified the accuracy of the model. The research results provide a theoretical basis for the control and prediction of the process and the optimization of the process parameters in the hydrolysis process of titanium liquid in industrial production.