Abstract: This is a paper in the field of mineral processing engineering.With the continuous development of mineral processing technology and the improvement of the degree of attention to mineral resources, more and more researches on the comprehensive utilization of tailings have been carried out. Chemical multivariate analysis, SEM and other techniques were used to characterize the copper ore in a vanadium titanomagnetite iron tailings, the study shows that the main valence element is copper, and mainly exists in the form of copper sulfide. A vanadium-titanium magnetite tailings in Hebei was used as a research object. Using butyl xanthate, A8 and MK305 for flotation recovery of copper in iron tailings, it is determined that the optimum flotation technical index is obtained when the A8∶MK305 dosage ratio is 1∶1 and the crude collector dosage is 45 g/t, 2^# oil is 7.5 g/t, through single collector test, combined collector test, collector dosage test and 2^#oil dosage test. The results of closed circuit test show that the coarse concentrate obtained after one coarse separation and one sweep of iron tailings is ground again to -0.074 mm content ≥85%, and the copper concentrate of 18.94% grade can be obtained by adding quicklime 12 kg/t, coarse concentrate after one coarse separation, three cleaning and two sweep operation, and the recovery rate is 60.88%. In this experiment, the recovery and utilization of metal copper in iron tailings are realized.