Abstract: Zinc calcine with high Fe content is leached with a large amount of Fe at the same time, which affects the subsequent operation. In order to solve this problem, the high iron zinc calcine of a company in Shaanxi was taken as the research object. The influence factors of Zn and Fe leaching rate were analyzed by studying the initial acidity, leaching temperature and solid-liquid ratio. The leaching process was optimized to improve the leaching rate of Zn and reduce the leaching rate of Fe. The results show that the effect of temperature on leaching rate of Zn and Fe is different in different sulfuric acid concentration leaching system. When the sulfuric acid dosage is insufficient, the temperature has no obvious effect on the leaching of Zn and Fe. When the sulfuric acid is excessive, the temperature will affect the leaching of Zn and Fe, especially for Fe. Initial acidity 90 g/L, leaching temperature 60 ℃, solid-liquid ratio 10:1, stirring speed 600 r/min are ideal leaching conditions.