Abstract: This is an article in the field of mineral processing engineering. Froth flotation is the main method for separating mineral particles. However, the conventional bubble size used in traditional flotation technology is relatively large, and the separation effect of fine particles is poor. As an important means to solve the problem of fine particle separation, nano bubbles have attracted extensive attention and in-depth research in the field of mineral flotation because of their unique physical and chemical properties. This article summarizes the research progress in the formation, preparation and stability of nano bubbles, introduces the application of nano bubble flotation in mineral processing and environmental treatment, and looks forward to the future research and development of nano bubble flotation.