Abstract: This is an article in the field of mineral processing engineering. The beryllium ore in Hunan Province contains 0.47% BeO and 44.86% CaF₂. The beryllium ore is chrysoberyl. The main gangue minerals are chlorite, mica, calcite, dolomite, etc. The disseminated particle size of beryllium ores is relatively fine, closely associated with chlorite, calcite, etc. So it is difficult to beneficiate. The beneficiation process flow is adopted by flotation of the sulphide ore first, then preferential flotation of fluorite, and the last reverse flotation of gangue minerals after flotation tailings deslimed. At the condition of the grinding fineness -0.074 mm accounted for 80%, the combined collectors of butylxanthate + ammonium dibutyldithiophosphate + sodium diethyldithiocarbamate for flotation were used to remove sulfide ores. Then fluorite concentrate with CaF₂ grade of 96.32% and recovery rate of 70.34% were obtained by flotation of fluorite with the combined collectors oxidized paraffinum sodium salt + sodium oleate. After the flotation tailings are deslimed, reverse flotation of gangue minerals is adopted and the beryllium concentrate with BeO grade of 1.57% and recovery rate of 67.95% is obtained. The subsequent beryllium concentrate can be extracted by metallurgical method to obtain beryllium oxide products. This process realizes the multipurpose recovery of beryllium ores of chrysoberyl type and fluorite ores, and provides a reference for the development and utilization of the same type of beryllium ores.