Abstract: Objective To overcome the shortcomings of amine collectors and achieve efficient separation of iron and silicon in iron ores, this article develops an amine-alcohol compound collector for the flotation of fine mixed iron ores. Method Comparative flotation tests of quaternary amine (JJA), quaternary amine + isooctanol (CJJA) were carried out with quartz and mixed magneto-hematite pure minerals. Result The single mineral flotation tests showed that CJJA gave good results in iron ore flotation with an optimum amine to alcohol ratio of 3∶1. The results of the actual mineral single-factor experiment are basically consistent with those of the single-mineral flotation experiment. The results of the actual mineral flotation open-circuit experiment show that when CJJA is used as the collector, at the conditions of an optimal pH value of 6 to 7, a collector dosage of 135 g/t, and an inhibitor dosage of 800 g/t, the grade of iron concentrate obtained is 66.58%. The recovery rate of iron concentrate is an excellent indicator of 80.84%. Conclusion The infrared spectral analysis showed that CJJA had a stronger affinity for the surface of quartz, probably due to the formation of co-adsorption and hydrogen bonding between alcohol and amine molecules, which made it easier to separate quartz from iron ores by flotation.