Abstract: During the mining process, a significant amount of mine water is generated. In order to improve the utilization rate of mine water resources and alleviate the shortage of water resources, this study focuses on the high suspended solids mine water from a magnetite mine in Tangshan, Hebei Province, China. The research investigates the combined effects of inorganic coagulants and organic polymers on the reduction of turbidity in mine water and explores the optimal coagulation conditions. Experimental results show that the combined use of inorganic and organic coagulants is more effective in treating mine water than using single inorganic or organic coagulants. At the conditions of adding 200 mg/L of polyaluminum chloride (PAC) and 2 mg/L of anionic polyacrylamide (APAM) in the staged dosing process, with a stirring speed of 150 r/min and the mine water temperature at 20 ℃, the turbidity of the treated mine water is 4.53 NTU, with a turbidity removal rate of 98.82%. By optimizing the experimental conditions using response surface methodology, the turbidity of the treated mine water is further reduced to 4.36 NTU, with a turbidity removal rate of 98.86%. The model has a high accuracy, and the treated mine water meets the requirements for industrial water use.