Abstract: By optimizing the grinding process and reagent system of flotation operation before cyanidation leaching, the overgrinding of gold concentrate is avoided, and the efficient comprehensive recovery of associated minerals is realized, which increases the recovery rates of copper, lead and zinc by 18.99%, 5.76% and 36.79% respectively. The leaching test of flotation products before leaching shows that the direct cyanide leaching of high copper concentrate and low sulfur concentrate can reach the existing production process indicators. When the high sulfur concentrate is finely ground to -0.037 mm and the content is 98.1%, the gold and silver leaching rates in the cyanide residue are 93.59% and 78.81% respectively, reaching or even exceeding the existing production indicators. On the basis of ensuring the leaching rate of gold and silver, this study realized the efficient recovery of associated minerals, reduced the grinding cost, and greatly improved the economic benefits of the enterprise.