Abstract: This is an article in the field of earth sciences. Manganese ore is one of the strategic minerals in short supply in China. The area of Northern Guizhou-Eastern Yunnan is the most typical distribution area of manganese ore in Permian, which is also rare in the Late Paleozoic in the world. It is rich in manganese ore resources and has great prospecting potential, so it is called "Zunyi type manganese ore". The results show that the manganese ore is produced in the late Permian Maokou, and its distribution is strictly controlled by the northern Guizhou rift basin. The manganese ore is formed in the center of graben basin by exhalation deposition, but no manganese ore is distributed in the barrier area, and the ore-body spatial distribution direction is basically consistent with the basin distribution direction. Among them, manganese ore in Zunyi - western Guizhou area is spatially distributed in the basin facies area, and can be divided into three manganese ore facies belts, namely, the central phase, the transition phase and the edge, which further indicates the specific metallogenic location of manganese ore and shows that the manganese ore is controlled by the center of the basin. Based on the Zunyi-Xuanwei manganese ore belt, it can be divided into four manganese ore concentration areas in the Zunyi-Qianxi manganese ore mineralization subzone: Shenxi-Bali, Longping-Xinglong, Tuanxi-Shangji and Qianxi, and two manganese ore concentration areas in shuicheng - Xuanwei manganese ore mineralization subzone: Shuicheng - Nayong and Gexue.The research results are of great significance to search for Permian concealed manganese deposits in northern Guizhou and eastern Yunnan and to carry out metallogenic prediction.