Abstract: The gold mine in a certain place in Shandong contains 0.8～1.0 g/t Au on average, which is a low-grade gold mine. Because the ore contains low gold, in order to reduce the cost of beneficiation and effectively recover valuable metals, detailed process mineralogical research is carried out on the ore. The study found that the natural type of the ore is quartz pyrite veins, and the industrial type is medium-sulfur gold ore. The metal minerals in the ore are mainly sulfides, mainly pyrite, followed by galena, sphalerite, and a small amount of chalcopyrite. Non-metallic minerals are mainly quartz, sericite, etc. In the ore, the particle size of pyrite is relatively coarse, and the particle size of galena, sphalerite, chalcopyrite, etc. is relatively fine. Pyrite and galena are closely related to gold and are the main carrier minerals for gold. Natural gold is mainly fine-grained gold, mostly distributed in inclusions. According to the research results of process mineralogy, it is recommended to adopt the "gravity separation + flotation" process, which not only achieves higher concentrate indicators, but also reduces the cost of mineral processing.