Abstract: In this paper, one-step neutralization process using lime slurry stimulated in the on-site process was conducted as a reference. The adding method of reagent, mixing of reagents, the type of water, and times of adding reagent on the pH value of copper raffinate were investigated. Moreover, the production of neutral slag and cost evaluation of reagents under the condition of various neutralization processes were initially predicted. The test results showed that the wet addition method has better effect than that of the dry one in the neutral performance on the copper raffinate. Compared with one-step neutralization process, the two-step neutralization process using lime slurry has lower cost and shorter reaction time. While neutralization using limestone is used as the first step and the second step using lime slurry, the agent consumption of limestone is easy to control, the amount of slag is the least and the cost of the total reagents is the lowest one.