Abstract: In order to separate different minerals at the same time according to density and grain size of mineral particles, the combined separation process of horizontal water flow and vibration and the coupling method of EDEM-FLUENT were used, mineral recovery and impurity rate used as the evaluation index. The separation behavior of mineral particles in the separation device was simulated, and the influence of different process parameters on the separation effect of mineral particles was discussed. The results show that the selected separation process can effectively separate mineral particles according to the density of mineral particles and size of mineral particles. The addition of vibrating screen can greatly reduce the impurity content of mineral particles in the separated products.The optimal parameters of the sorting device are: screen surface inclination Angle is 0°, vibration frequency is 10 Hz, amplitude is 3 mm, particle inlet bottom width is 7 mm. By this time recovery 96.8% and containing impurity rate 5.67% were obtained.