Abstract: In order to realize the desilication of phosphate rock by reverse flotation, the selection of appropriate amine collectors and reasonable flotation conditions are the key to the desilication of phosphate rock by reverse flotation. Through flotation experiments, the collection effects of four different amine collectors, including fatty amines, amine ethers, ether amines and oxidized amines, on quartz were compared. The experiments show that different amine collectors have different flotation properties for collophanite at the same pH value. In weakly alkaline medium, the basic order of the collection capacity of fatty amine reagents for SiO₂ is as follows: the flotation collection performance of coconut diamine for silicate minerals is better than that of n-octylamine, dodecylamine, coconut diamine and isothirteen amine, but the loss rate of phosphorus by isothirteen amine reagent is lower, followed by coconut diamine, dodecylamine, coconut oil amine and n-octylamine had greater loss of phosphorus. The collection capacity of amine ethers for SiO₂ is as follows: the collection capacity of coconut amine polyoxyethylene ether for silicate minerals is stronger than that of dodecylamine polyoxyethylene ether, and the P₂O₅ loss rate of flotation tailings of dodecylamine polyoxyethylene ether is higher than that of coconut amine polyoxyethylene ether; The collection capacity of ether amine reagents for SiO₂ is as follows: the collection capacity of isodecanetramine for silicate minerals is weaker than that of C10 ether amine, and the loss rate of P₂O₅ of isodecanetramine flotation tailings is higher than that of C10 ether grease; The test results show that the flotation performance of the same type of amine reagent is basically similar, and there are some small differences. The collection capacity of fatty diamine with the same carbon chain composition for collophanite is stronger than fatty monoamine. The basic order of flotation performance from strong to weak is diamine > monoamine > ether amine > amine ether > oxide amine.