Abstract: Through flotation tests and desorption tests, the desorption behavior of methylcellulose from the surface of talc at different temperatures and its influence on the flotation of talc were studied. The results show that the natural floatability of talc is good. The depressive effect on methylcellulose on talc is enhanced with the increase of pulp temperature. Washing can weaken the depressive effect on methylcellulose on talc, increase the flotation recovery of talc, and increase the flotation recovery of talc more at low temperature. The flotation separation of chalcopyrite and talc can be realized by using methylcellulose.