Abstract: A high-calcite type fluorite ore in Xinjiang contains 25.47% fluorite and 41.67% calcite. To effectively inhibit calcite, thereby obtaining a qualified fluorite concentrate and improving the mineral recovery rate, researchers carried out a flotation test research. At the condition of a grinding fineness of -0.074 mm 65%, the test used collector EM-OL8, depressant EMN, and modifier SSB, and the researchers adopted a closed-circuit test process of "two roughing one scavenging eight cleaning , with middlings Ⅱ-Ⅷ returning in sequence, and middling Ⅰ and scavenging concentrate returning to roughing Ⅱ". The test obtained fluorite concentrate was achieved with a yield of 22.02%, a CaF₂ grade of 97.38%, and a recovery rate of 84.20%, which provides a technical foundation for subsequent industrial production.